A biophysical rationale for the selective inhibition of PTP1B over TCPTP by nonpolar terpenoids

Protein tyrosine phosphatases (PTPs) are emerging drug targets for many diseases, including type 2 diabetes, obesity, and cancer. However, a high degree of structural similarity between the catalytic domains of these enzymes has made the development of selective pharmacological inhibitors an enormou...

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Detalles Bibliográficos
Autores principales: Friedman, Anika J., Padgette, Hannah M., Kramer, Levi, Liechty, Evan T., Donovan, Gregory W., Fox, Jerome M., Shirts, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153121/
https://www.ncbi.nlm.nih.gov/pubmed/37131728
http://dx.doi.org/10.1101/2023.04.17.537234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153121/
https://www.ncbi.nlm.nih.gov/pubmed/37131728
http://dx.doi.org/10.1101/2023.04.17.537234

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