Engineering Nme2Cas9 Adenine Base Editors with Improved Activity and Targeting Scope

Nme2Cas9 has been established as a genome editing platform with compact size, high accuracy, and broad targeting range, including single-AAV-deliverable adenine base editors. Here, we have engineered Nme2Cas9 to further increase the activity and targeting scope of compact Nme2Cas9 base editors. We f...

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Detalles Bibliográficos
Autores principales: Bamidele, Nathan, Zhang, Han, Dong, Xiaolong, Gaston, Nicholas, Cheng, Haoyang, Kelly, Karen, Watts, Jonathan K., Xie, Jun, Gao, Guangping, Sontheimer, Erik J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153126/
https://www.ncbi.nlm.nih.gov/pubmed/37131611
http://dx.doi.org/10.1101/2023.04.14.536905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153126/
https://www.ncbi.nlm.nih.gov/pubmed/37131611
http://dx.doi.org/10.1101/2023.04.14.536905

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