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Proline provides a nitrogen source in the retinal pigment epithelium to synthesize and export amino acids for the neural retina

It is known that metabolic defects in the retinal pigment epithelium (RPE) can cause degeneration of its neighboring photoreceptors in the retina, leading to retinal degenerative diseases such as age-related macular degeneration. However, how RPE metabolism supports the health of the neural retina r...

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Detalles Bibliográficos
Autores principales: Zhu, Siyan, Xu, Rong, Engel, Abbi L., Wang, Yekai, McNeel, Rachel, Hurley, James B., Chao, Jennifer R., Du, Jianhai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153141/
https://www.ncbi.nlm.nih.gov/pubmed/37131780
http://dx.doi.org/10.1101/2023.04.18.537355