Pharmacological inhibition of CLK2 activates YAP by promoting alternative splicing of AMOTL2

Yes-associated protein (YAP), the downstream effector of the evolutionarily conserved Hippo pathway, promotes cellular proliferation and coordinates certain regenerative responses in mammals. Small molecule activators of YAP may therefore display therapeutic utility in treating disease states involv...

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Detalles Bibliográficos
Autores principales: Bulos, Maya L., Grzelak, Edyta M., Li-Ma, Chloris, Chen, Emily, Hull, Mitchell, Johnson, Kristen A., Bollong, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153145/
https://www.ncbi.nlm.nih.gov/pubmed/37131806
http://dx.doi.org/10.1101/2023.04.19.537449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153145/
https://www.ncbi.nlm.nih.gov/pubmed/37131806
http://dx.doi.org/10.1101/2023.04.19.537449

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