In Vitro Modeling of CD8 T Cell Exhaustion Enables CRISPR Screening to Reveal a Role for BHLHE40

Identifying novel molecular mechanisms of exhausted CD8 T cells (T(ex)) is a key goal of improving immunotherapy of cancer and other diseases. However, high-throughput interrogation of in vivo T(ex) can be costly and inefficient. In vitro models of T(ex) are easily customizable and quickly generate...

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Detalles Bibliográficos
Autores principales: Wu, Jennifer E., Manne, Sasikanth, Ngiow, Shin Foong, Baxter, Amy E., Huang, Hua, Freilich, Elizabeth, Clark, Megan L., Lee, Joanna H., Chen, Zeyu, Khan, Omar, Staupe, Ryan P., Huang, Yinghui J., Shi, Junwei, Giles, Josephine R., Wherry, E. John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153201/
https://www.ncbi.nlm.nih.gov/pubmed/37131713
http://dx.doi.org/10.1101/2023.04.17.537229

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153201/
https://www.ncbi.nlm.nih.gov/pubmed/37131713
http://dx.doi.org/10.1101/2023.04.17.537229

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