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Kinetic investigation reveals an HIV-1 Nef-dependent increase in AP-2 recruitment and productivity at endocytic sites
Lentiviruses express non-enzymatic accessory proteins whose function is to subvert cellular machinery in the infected host. The HIV-1 accessory protein Nef hijacks clathrin adaptors to degrade or mislocalize host proteins involved in antiviral defenses. Here, we investigate the interaction between N...
Autores principales: | Iwamoto, Yuichiro, Ye, Anna, Shirazinejad, Cyna, Hurley, James H., Drubin, David G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153213/ https://www.ncbi.nlm.nih.gov/pubmed/37131815 http://dx.doi.org/10.1101/2023.04.18.537262 |
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