Nuclear bodies protect phase separated proteins from degradation in stressed proteome

RNA-binding proteins (RBPs) containing intrinsically disordered domains undergo liquid-liquid phase separation to form nuclear bodies under stress conditions. This process is also connected to the misfolding and aggregation of RBPs, which are associated with a series of neurodegenerative diseases. H...

Descripción completa

Detalles Bibliográficos
Autores principales: Jung, Kwan Ho, Sun, Jiarui, Hsiung, Chia-Heng, Lance Lian, Xiaojun, Liu, Yu, Zhang, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153235/
https://www.ncbi.nlm.nih.gov/pubmed/37131610
http://dx.doi.org/10.1101/2023.04.19.537522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153235/
https://www.ncbi.nlm.nih.gov/pubmed/37131610
http://dx.doi.org/10.1101/2023.04.19.537522

Ejemplares similares