Elevated CSF angiopoietin-2 correlates with blood-brain barrier leakiness and markers of neuronal injury in early Alzheimer’s disease

Breakdown of the neurovascular unit in early Alzheimer’s disease (AD) leads to leakiness of the blood-brain barrier (BBB), contributing to cognitive decline and disease pathology. Vascular stability depends on angiopoietin-1 (ANGPT1) signalling, antagonised by angiopoietin-2 (ANGPT2) upon endothelia...

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Detalles Bibliográficos
Autores principales: Miners, James, van Hulle, Carol, Ince, Selvi, Jonaitis, Erin, Okonkwo, OC, Bendlin, Barbara, Johnson, Sterling, Carlsson, Cynthia, Asthana, Sanjay, Love, Seth, Blennow, Kaj, Zetterberg, Henrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153378/
https://www.ncbi.nlm.nih.gov/pubmed/37131622
http://dx.doi.org/10.21203/rs.3.rs-2722280/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153378/
https://www.ncbi.nlm.nih.gov/pubmed/37131622
http://dx.doi.org/10.21203/rs.3.rs-2722280/v1

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