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Elevated CSF angiopoietin-2 correlates with blood-brain barrier leakiness and markers of neuronal injury in early Alzheimer’s disease

Breakdown of the neurovascular unit in early Alzheimer’s disease (AD) leads to leakiness of the blood-brain barrier (BBB), contributing to cognitive decline and disease pathology. Vascular stability depends on angiopoietin-1 (ANGPT1) signalling, antagonised by angiopoietin-2 (ANGPT2) upon endothelia...

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Detalles Bibliográficos
Autores principales:	Miners, James, van Hulle, Carol, Ince, Selvi, Jonaitis, Erin, Okonkwo, OC, Bendlin, Barbara, Johnson, Sterling, Carlsson, Cynthia, Asthana, Sanjay, Love, Seth, Blennow, Kaj, Zetterberg, Henrik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153378/ https://www.ncbi.nlm.nih.gov/pubmed/37131622 http://dx.doi.org/10.21203/rs.3.rs-2722280/v1

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