Pharmacophore Variants of the Macrocyclic Peptide Triazole Inactivator of HIV-1 Env

Previously we established a family of macrocyclic peptide triazoles (cPTs) that inactivate the Env protein complex of HIV-1, and identified the pharmacophore that engages Env’s receptor binding pocket. Here, we examined the hypothesis that the side chains of both components of the triazole Pro - Trp...

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Detalles Bibliográficos
Autores principales: Gupta, Monisha, Canziani, Gabriela, Ang, Charles, Mohammadi, Mohammadjavad, Abrams, Cameron F., Yang, Derek, Smith, Amos B., Chaiken, Irwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153383/
https://www.ncbi.nlm.nih.gov/pubmed/37131733
http://dx.doi.org/10.21203/rs.3.rs-2814722/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153383/
https://www.ncbi.nlm.nih.gov/pubmed/37131733
http://dx.doi.org/10.21203/rs.3.rs-2814722/v1

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