Evolutionary paths that link orthogonal pairs of binding proteins

Some protein binding pairs exhibit extreme specificities that functionally insulate them from homologs. Such pairs evolve mostly by accumulating single-point mutations, and mutants are selected if their affinity exceeds the threshold required for function(1–4). Thus, homologous and high-specificity...

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Detalles Bibliográficos
Autores principales: Avizemer, Ziv, Martí-Gómez, Carlos, Hoch, Shlomo Yakir, McCandlish, David M., Fleishman, Sarel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153392/
https://www.ncbi.nlm.nih.gov/pubmed/37131620
http://dx.doi.org/10.21203/rs.3.rs-2836905/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153392/
https://www.ncbi.nlm.nih.gov/pubmed/37131620
http://dx.doi.org/10.21203/rs.3.rs-2836905/v1

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