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Evolutionary paths that link orthogonal pairs of binding proteins
Some protein binding pairs exhibit extreme specificities that functionally insulate them from homologs. Such pairs evolve mostly by accumulating single-point mutations, and mutants are selected if their affinity exceeds the threshold required for function(1–4). Thus, homologous and high-specificity...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Journal Experts
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153392/ https://www.ncbi.nlm.nih.gov/pubmed/37131620 http://dx.doi.org/10.21203/rs.3.rs-2836905/v1 |