Noncatalytic regulation of 18S rRNA methyltransferase DIMT1 in acute myeloid leukemia

Several rRNA-modifying enzymes install rRNA modifications while participating in ribosome assembly. Here, we show that 18S rRNA methyltransferase DIMT1 is essential for acute myeloid leukemia (AML) proliferation through a noncatalytic function. We reveal that targeting a positively charged cleft of...

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Detalles Bibliográficos
Autores principales: Gonskikh, Yulia, Stoute, Julian, Shen, Hui, Budinich, Krista, Pingul, Bianca, Schultz, Kollin, Elashal, Heidi, Marmorstein, Ronen, Shi, Junwei, Liu, Kathy Fange
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2023
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153457/
https://www.ncbi.nlm.nih.gov/pubmed/37024283
http://dx.doi.org/10.1101/gad.350298.122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153457/
https://www.ncbi.nlm.nih.gov/pubmed/37024283
http://dx.doi.org/10.1101/gad.350298.122

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