Cargando…

Noncatalytic regulation of 18S rRNA methyltransferase DIMT1 in acute myeloid leukemia

Several rRNA-modifying enzymes install rRNA modifications while participating in ribosome assembly. Here, we show that 18S rRNA methyltransferase DIMT1 is essential for acute myeloid leukemia (AML) proliferation through a noncatalytic function. We reveal that targeting a positively charged cleft of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gonskikh, Yulia, Stoute, Julian, Shen, Hui, Budinich, Krista, Pingul, Bianca, Schultz, Kollin, Elashal, Heidi, Marmorstein, Ronen, Shi, Junwei, Liu, Kathy Fange
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2023
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153457/ https://www.ncbi.nlm.nih.gov/pubmed/37024283 http://dx.doi.org/10.1101/gad.350298.122

Ejemplares similares

Human DIMT1 generates N(2)(6,6)A-dimethylation–containing small RNAs
por: Shen, Hui, et al.
Publicado: (2021)

The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis
por: Zorbas, Christiane, et al.
Publicado: (2015)

Allosteric role of the citrate synthase homology domain of ATP citrate lyase
por: Wei, Xuepeng, et al.
Publicado: (2023)

Noncatalytic Domains in DNA Glycosylases
por: Torgasheva, Natalia A., et al.
Publicado: (2022)

Antibiotic Streptolydigin Requires Noncatalytic Mg(2+) for Binding to RNA Polymerase
por: Zorov, Savva, et al.
Publicado: (2014)

Protein arginine N-methyltransferase 2 plays a noncatalytic role in the histone methylation activity of PRMT1
por: Rowley, Michael J., et al.
Publicado: (2023)

Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles
por: Serafimova, Iana M., et al.
Publicado: (2012)

Hypoxia‐inducible microRNA‐210 regulates the DIMT1‐IRF4 oncogenic axis in multiple myeloma
por: Ikeda, Sho, et al.
Publicado: (2017)

Ribosomal biogenesis regulator DIMT1 controls β-cell protein synthesis, mitochondrial function, and insulin secretion
por: Verma, Gaurav, et al.
Publicado: (2022)

Evolution of an Enzyme from a Noncatalytic Nucleic Acid Sequence
por: Gysbers, Rachel, et al.
Publicado: (2015)

Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo
por: Caserta, Enrico, et al.
Publicado: (2015)

PARP inhibitor shuts down the global translation of thyroid cancer through promoting Pol II binding to DIMT1 pause
por: Hou, Xiukun, et al.
Publicado: (2023)

A noncatalytic function of the ligation complex during nonhomologous end joining
por: Cottarel, Jessica, et al.
Publicado: (2013)

Noncatalytic Function of a JmjC Domain Protein Disrupts Heterochromatin
por: Bao, Kehan, et al.
Publicado: (2019)

Mechanism of the noncatalytic oxidation of soot using in situ transmission electron microscopy
por: Gao, Ming, et al.
Publicado: (2023)

A mitochondrial rRNA dimethyladenosine methyltransferase in Arabidopsis
por: Richter, Uwe, et al.
Publicado: (2010)

Noncatalytic Inhibition of Cyclic Nucleotide–gated Channels by Tyrosine Kinase Induced by Genistein
por: Molokanova, Elena, et al.
Publicado: (1999)

Understanding How Noncatalytic Carbohydrate Binding Modules Can Display Specificity for Xyloglucan
por: Luís, Ana S., et al.
Publicado: (2013)

There’s more to death than life: Noncatalytic functions in kinase and pseudokinase signaling
por: Mace, Peter D., et al.
Publicado: (2021)

The noncatalytic regions of the tyrosine kinase Tnk1 are important for activity and substrate specificity
por: Ahmed, Sultan, et al.
Publicado: (2022)

The Active Site of a Carbohydrate Esterase Displays Divergent Catalytic and Noncatalytic Binding Functions
por: Montanier, Cedric, et al.
Publicado: (2009)

Kinetic Study on the Preparation of Fumaric Acid from Maleic Acid by Batch Noncatalytic Isomerization
por: Chen, Wangmi, et al.
Publicado: (2019)

The double lives of phosphatases of regenerating liver: A structural view of their catalytic and noncatalytic activities
por: Gehring, Kalle, et al.
Publicado: (2021)

Influence of Water on Noncatalytic Oxidative Desulfurization of High-Sulfur Straight-Run Oil Fractions
por: Pyshyev, Serhiy, et al.
Publicado: (2022)

Relationship of Hair Regrowth Pattern in Alopecia Areata Patches According to DIMT Classification with Treatment Modalities and Patch Size: A Retrospective Cross-Sectional Analysis
por: Lim, Sung Ha, et al.
Publicado: (2022)

RNase E in the γ-Proteobacteria: conservation of intrinsically disordered noncatalytic region and molecular evolution of microdomains
por: Aït-Bara, Soraya, et al.
Publicado: (2014)

Noncatalytic chalcone isomerase-fold proteins in Humulus lupulus are auxiliary components in prenylated flavonoid biosynthesis
por: Ban, Zhaonan, et al.
Publicado: (2018)

Deubiquitinase Usp12 functions noncatalytically to induce autophagy and confer neuroprotection in models of Huntington’s disease
por: Aron, Rebecca, et al.
Publicado: (2018)

Neuroinflammation inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy
por: Zhang, Xiao-Wen, et al.
Publicado: (2022)

Dissection of the MEF2D-IRF8 transcriptional circuit dependency in acute myeloid leukemia
por: Pingul, Bianca Y., et al.
Publicado: (2022)

16S rRNA Methyltransferase RmtC in Salmonella enterica Serovar Virchow
por: Hopkins, Katie L., et al.
Publicado: (2010)

Crystal structure of ErmE - 23S rRNA methyltransferase in macrolide resistance
por: Stsiapanava, Alena, et al.
Publicado: (2019)

Research Updates of Plasmid-Mediated Aminoglycoside Resistance 16S rRNA Methyltransferase
por: Yang, Weiwei, et al.
Publicado: (2022)

Intense ultraviolet emission from needle-like WO(3 )nanostructures synthesized by noncatalytic thermal evaporation
por: Park, Sunghoon, et al.
Publicado: (2011)

The Roles of the Catalytic and Noncatalytic Activities of Rpd3L and Rpd3S in the Regulation of Gene Transcription in Yeast
por: Yeheskely-Hayon, Daniella, et al.
Publicado: (2013)

A noncatalytic function of the topoisomerase II CTD in Aurora B recruitment to inner centromeres during mitosis
por: Edgerton, Heather, et al.
Publicado: (2016)

Noncatalytic Oxidative Coupling of Methane (OCM): Gas-Phase Reactions in a Jet Stirred Reactor (JSR)
por: Wang, Haoyi, et al.
Publicado: (2021)

Structural Insights into the Methylation of C1402 in 16S rRNA by Methyltransferase RsmI
por: Zhao, Mohan, et al.
Publicado: (2016)

The critical function of the plastid rRNA methyltransferase, CMAL, in ribosome biogenesis and plant development
por: Zou, Meijuan, et al.
Publicado: (2020)

Engineering the conserved and noncatalytic residues of a thermostable β-1,4-endoglucanase to improve specific activity and thermostability
por: Chen, Xiutao, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ivag4dh1m5b39agtrpev2u541f