Cargando…

Toward a pan-SARS-CoV-2 vaccine targeting conserved epitopes on spike and non-spike proteins for potent, broad and durable immune responses

BACKGROUND: The SARS-CoV-2 non-Spike (S) structural protein targets on nucleocapsid (N), membrane (M) and envelope (E), critical in the host cell interferon response and memory T-cell immunity, are grossly overlooked in COVID vaccine development. The current Spike-only vaccines bear an intrinsic sho...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Chang Yi, Peng, Wen-Jiun, Kuo, Be-Sheng, Ho, Yu-Hsin, Wang, Min-Sheng, Yang, Ya-Ting, Chang, Po-Yen, Shen, Yea-Huei, Hwang, Kao-Pin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153712/ https://www.ncbi.nlm.nih.gov/pubmed/37079651 http://dx.doi.org/10.1371/journal.ppat.1010870

Ejemplares similares

Pan-coronavirus epitope buried in spike
por: Hofer, Ursula
Publicado: (2022)

Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit
por: Hurlburt, Nicholas K., et al.
Publicado: (2022)

A highly conserved epitope on the spike protein of infectious bronchitis virus
por: Wang, L., et al.
Publicado: (1995)

Identification of a promiscuous conserved CTL epitope within the SARS-CoV-2 spike protein
por: Jiang, Sheng, et al.
Publicado: (2022)

Coronavirus epitope prediction from highly conserved region of spike protein
por: Yurina, Valentina
Publicado: (2020)

Targeting the Spike Receptor Binding Domain Class V Cryptic Epitope by an Antibody with Pan-Sarbecovirus Activity
por: Jensen, Jaime L., et al.
Publicado: (2023)

Identification of Conserved Epitopes in SARS-CoV-2 Spike and Nucleocapsid Protein
por: Forcelloni, Sergio, et al.
Publicado: (2021)

Enhancing epitope of PEDV spike protein
por: Thavorasak, Techit, et al.
Publicado: (2022)

SARS-CoV-2 variants of concern: spike protein mutational analysis and epitope for broad neutralization
por: Mannar, Dhiraj, et al.
Publicado: (2022)

Novel chimeric proteins mimicking SARS-CoV-2 spike epitopes with broad inhibitory activity
por: Cano-Muñoz, Mario, et al.
Publicado: (2022)

Deep repertoire mining uncovers ultra-broad coronavirus neutralizing antibodies targeting multiple spike epitopes
por: Hurtado, Jonathan, et al.
Publicado: (2023)

35B5 antibody potently neutralizes SARS-CoV-2 Omicron by disrupting the N-glycan switch via a conserved spike epitope
por: Wang, Xiaofei, et al.
Publicado: (2022)

Identification of three conserved linear B cell epitopes on the SARS-CoV-2 spike protein
por: Wang, Aiping, et al.
Publicado: (2022)

Conserved Neutralizing Epitopes on the N-Terminal Domain of Variant SARS-CoV-2 Spike Proteins
por: Wang, Zijun, et al.
Publicado: (2022)

Epitope mapping of spike identifies variant-resistant antibodies
por: Flemming, Alexandra
Publicado: (2021)

Identification of a conserved S2 epitope present on spike proteins from all highly pathogenic coronaviruses
por: Silva, Rui P, et al.
Publicado: (2023)

Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on Spike and provides antiviral protection through inhalation-based delivery in non-human primates
por: Hermet, Paule, et al.
Publicado: (2023)

A broad and potent neutralization epitope in SARS-related coronaviruses
por: Yuan, Meng, et al.
Publicado: (2022)

A broad and potent neutralization epitope in SARS-related coronaviruses
por: Yuan, Meng, et al.
Publicado: (2022)

The Global Spike: Conserved Dendritic Properties Enable Unique Ca(2+) Spike Generation in Low-Threshold Spiking Neurons
por: Connelly, William M., et al.
Publicado: (2015)

Heterologous SARS-CoV-2 spike protein booster elicits durable and broad antibody responses against the receptor-binding domain
por: Takano, Tomohiro, et al.
Publicado: (2023)

Identification of a novel conserved HLA-A*0201-restricted epitope from the spike protein of SARS-CoV
por: Lv, Yanbo, et al.
Publicado: (2009)

Delta breakthrough infections elicit potent, broad and durable neutralizing antibody responses
por: Walls, Alexandra C., et al.
Publicado: (2021)

Identification of two antigenic epitopes on SARS-CoV spike protein
por: Hua, Ronghong, et al.
Publicado: (2004)

COVID-19 vaccination recruits and matures cross-reactive antibodies to conserved epitopes in endemic coronavirus Spike proteins
por: Elko, Evan A, et al.
Publicado: (2022)

Cytotoxic T lymphocytes targeting a conserved SARS-CoV-2 spike epitope are efficient serial killers
por: Fathi, Mohsen, et al.
Publicado: (2022)

Comirnaty-Elicited and Convalescent Sera Recognize Different Spike Epitopes
por: Hein, Sascha, et al.
Publicado: (2021)

Identification of broad, potent antibodies to functionally constrained regions of SARS-CoV-2 spike following a breakthrough infection
por: Guenthoer, Jamie, et al.
Publicado: (2023)

Glycan Masking of Epitopes in the NTD and RBD of the Spike Protein Elicits Broadly Neutralizing Antibodies Against SARS-CoV-2 Variants
por: Lin, Wei-Shuo, et al.
Publicado: (2021)

A hierarchical spike-and-slab model for pan-cancer survival using pan-omic data
por: Samorodnitsky, Sarah, et al.
Publicado: (2022)

Self-assembling SARS-CoV-2 spike-HBsAg nanoparticles elicit potent and durable neutralizing antibody responses via genetic delivery
por: Liu, Cuiping, et al.
Publicado: (2023)

Cross-reactive antibodies elicited to conserved epitopes on SARS-CoV-2 spike protein after infection and vaccination
por: Geanes, Eric S., et al.
Publicado: (2022)

COVID-19 vaccination elicits an evolving, cross-reactive antibody response to epitopes conserved with endemic coronavirus spike proteins
por: Elko, Evan A., et al.
Publicado: (2022)

A Novel Conserved Linear Neutralizing Epitope on the Receptor-Binding Domain of the SARS-CoV-2 Spike Protein
por: Hua, Rong-Hong, et al.
Publicado: (2023)

Firing-rate models for neurons with a broad repertoire of spiking behaviors
por: Heiberg, Thomas, et al.
Publicado: (2013)

Firing-rate models for neurons with a broad repertoire of spiking behaviors
por: Heiberg, Thomas, et al.
Publicado: (2018)

Stabilized coronavirus spike stem elicits a broadly protective antibody
por: Hsieh, Ching-Lin, et al.
Publicado: (2021)

Prediction of TGEV Spike Protein Secondary Structure and B Cell Epitopes
por: Yu, Tian-fei, et al.
Publicado: (2012)

Epitopes on the spike protein of a nephropathogenic strain of infectious bronchitis virus
por: Parr, Rebecca L., et al.
Publicado: (1993)

Computational epitope map of SARS-CoV-2 spike protein
por: Sikora, Mateusz, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_hk74qvu7v11q54cp1a693shsil