Whole exome sequencing analysis of canine urothelial carcinomas without BRAF V595E mutation: Short in-frame deletions in BRAF and MAP2K1 suggest alternative mechanisms for MAPK pathway disruption

Molecular profiling studies have shown that 85% of canine urothelial carcinomas (UC) harbor an activating BRAF V595E mutation, which is orthologous to the V600E variant found in several human cancer subtypes. In dogs, this mutation provides both a powerful diagnostic marker and a potential therapeut...

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Detalles Bibliográficos
Autores principales: Thomas, Rachael, Wiley, Claire A., Droste, Emma L., Robertson, James, Inman, Brant A., Breen, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153751/
https://www.ncbi.nlm.nih.gov/pubmed/37079639
http://dx.doi.org/10.1371/journal.pgen.1010575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10153751/
https://www.ncbi.nlm.nih.gov/pubmed/37079639
http://dx.doi.org/10.1371/journal.pgen.1010575

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