Transmembrane protein CD69 acts as an S1PR1 agonist

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The activation of Sphingosine-1-phosphate receptor 1 (S1PR1) by S1P promotes lymphocyte egress from lymphoid organs, a process critical for immune surveillance and T cell effector activity. Multiple drugs that inhibit S1PR1 function are in use clinically for the treatment of autoimmune diseases. Clu...

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Detalles Bibliográficos
Autores principales: Chen, Hongwen, Qin, Yu, Chou, Marissa, Cyster, Jason G, Li, Xiaochun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154026/
https://www.ncbi.nlm.nih.gov/pubmed/37039481
http://dx.doi.org/10.7554/eLife.88204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154026/
https://www.ncbi.nlm.nih.gov/pubmed/37039481
http://dx.doi.org/10.7554/eLife.88204

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