The burden of rare protein-truncating genetic variants on human lifespan

Genetic predisposition has been shown to contribute substantially to the age at which we die. Genome-wide association studies (GWASs) have linked more than 20 loci to phenotypes related to human lifespan(1). However, little is known about how lifespan is impacted by gene loss of function. Through wh...

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Detalles Bibliográficos
Autores principales: Liu, Jimmy Z., Chen, Chia-Yen, Tsai, Ellen A., Whelan, Christopher D., Sexton, David, John, Sally, Runz, Heiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154195/
https://www.ncbi.nlm.nih.gov/pubmed/37117740
http://dx.doi.org/10.1038/s43587-022-00182-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154195/
https://www.ncbi.nlm.nih.gov/pubmed/37117740
http://dx.doi.org/10.1038/s43587-022-00182-3

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