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The burden of rare protein-truncating genetic variants on human lifespan
Genetic predisposition has been shown to contribute substantially to the age at which we die. Genome-wide association studies (GWASs) have linked more than 20 loci to phenotypes related to human lifespan(1). However, little is known about how lifespan is impacted by gene loss of function. Through wh...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group US
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154195/ https://www.ncbi.nlm.nih.gov/pubmed/37117740 http://dx.doi.org/10.1038/s43587-022-00182-3 |