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SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response

Reports of post-acute COVID-19 syndrome, in which the inflammatory response persists even after SARS-CoV-2 has disappeared, are increasing(1), but the underlying mechanisms of post-acute COVID-19 syndrome remain unknown. Here, we show that SARS-CoV-2-infected cells trigger senescence-like cell-cycle...

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Detalles Bibliográficos
Autores principales: Tsuji, Shunya, Minami, Shohei, Hashimoto, Rina, Konishi, Yusuke, Suzuki, Tatsuya, Kondo, Tamae, Sasai, Miwa, Torii, Shiho, Ono, Chikako, Shichinohe, Shintaro, Sato, Shintaro, Wakita, Masahiro, Okumura, Shintaro, Nakano, Sosuke, Matsudaira, Tatsuyuki, Matsumoto, Tomonori, Kawamoto, Shimpei, Yamamoto, Masahiro, Watanabe, Tokiko, Matsuura, Yoshiharu, Takayama, Kazuo, Kobayashi, Takeshi, Okamoto, Toru, Hara, Eiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154207/
https://www.ncbi.nlm.nih.gov/pubmed/37117754
http://dx.doi.org/10.1038/s43587-022-00170-7