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piRNAs regulate a Hedgehog germline-to-soma pro-aging signal
The reproductive system regulates somatic aging through competing anti- and pro-aging signals. Germline removal extends somatic lifespan through conserved pathways including insulin and mammalian target-of-rapamycin signaling, while germline hyperactivity shortens lifespan through unknown mechanisms...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group US
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154208/ https://www.ncbi.nlm.nih.gov/pubmed/37118518 http://dx.doi.org/10.1038/s43587-022-00329-2 |