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piRNAs regulate a Hedgehog germline-to-soma pro-aging signal

The reproductive system regulates somatic aging through competing anti- and pro-aging signals. Germline removal extends somatic lifespan through conserved pathways including insulin and mammalian target-of-rapamycin signaling, while germline hyperactivity shortens lifespan through unknown mechanisms...

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Detalles Bibliográficos
Autores principales: Shi, Cheng, Murphy, Coleen T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154208/
https://www.ncbi.nlm.nih.gov/pubmed/37118518
http://dx.doi.org/10.1038/s43587-022-00329-2

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