A structural basis for prion strain diversity

Recent cryogenic electron microscopy (cryo-EM) studies of infectious, ex vivo, prion fibrils from hamster 263K and mouse RML prion strains revealed a similar, parallel in-register intermolecular β-sheet (PIRIBS) amyloid architecture. Rungs of the fibrils are composed of individual prion protein (PrP...

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Detalles Bibliográficos
Autores principales: Manka, Szymon W., Wenborn, Adam, Betts, Jemma, Joiner, Susan, Saibil, Helen R., Collinge, John, Wadsworth, Jonathan D. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154210/
https://www.ncbi.nlm.nih.gov/pubmed/36646960
http://dx.doi.org/10.1038/s41589-022-01229-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154210/
https://www.ncbi.nlm.nih.gov/pubmed/36646960
http://dx.doi.org/10.1038/s41589-022-01229-7

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