Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer’s disease mouse models

Microglia and complement can mediate neurodegeneration in Alzheimer’s disease (AD). By integrative multi-omics analysis, here we show that astrocytic and microglial proteins are increased in Tau(P301S) synapse fractions with age and in a C1q-dependent manner. In addition to microglia, we identified...

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Detalles Bibliográficos
Autores principales: Dejanovic, Borislav, Wu, Tiffany, Tsai, Ming-Chi, Graykowski, David, Gandham, Vineela D., Rose, Christopher M., Bakalarski, Corey E., Ngu, Hai, Wang, Yuanyuan, Pandey, Shristi, Rezzonico, Mitchell G., Friedman, Brad A., Edmonds, Rose, De Mazière, Ann, Rakosi-Schmidt, Raphael, Singh, Tarjinder, Klumperman, Judith, Foreman, Oded, Chang, Michael C., Xie, Luke, Sheng, Morgan, Hanson, Jesse E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154216/
https://www.ncbi.nlm.nih.gov/pubmed/37118504
http://dx.doi.org/10.1038/s43587-022-00281-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154216/
https://www.ncbi.nlm.nih.gov/pubmed/37118504
http://dx.doi.org/10.1038/s43587-022-00281-1

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