Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II

Etoposide is a broadly employed chemotherapeutic and eukaryotic topoisomerase II poison that stabilizes cleaved DNA intermediates to promote DNA breakage and cytotoxicity. How etoposide perturbs topoisomerase dynamics is not known. Here we investigated the action of etoposide on yeast topoisomerase...

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Detalles Bibliográficos
Autores principales: Le, Tung T., Wu, Meiling, Lee, Joyce H., Bhatt, Neti, Inman, James T., Berger, James M., Wang, Michelle D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154222/
https://www.ncbi.nlm.nih.gov/pubmed/36717711
http://dx.doi.org/10.1038/s41589-022-01235-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154222/
https://www.ncbi.nlm.nih.gov/pubmed/36717711
http://dx.doi.org/10.1038/s41589-022-01235-9

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