Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy

The licensed drug rapamycin has potential to be repurposed for geroprotection. A key challenge is to avoid adverse side effects from continuous dosing. Here we show that geroprotective effects of chronic rapamycin treatment can be obtained with a brief pulse of the drug in early adulthood in female...

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Detalles Bibliográficos
Autores principales: Juricic, Paula, Lu, Yu-Xuan, Leech, Thomas, Drews, Lisa F., Paulitz, Jonathan, Lu, Jiongming, Nespital, Tobias, Azami, Sina, Regan, Jennifer C., Funk, Emilie, Fröhlich, Jenny, Grönke, Sebastian, Partridge, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154223/
https://www.ncbi.nlm.nih.gov/pubmed/37118497
http://dx.doi.org/10.1038/s43587-022-00278-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154223/
https://www.ncbi.nlm.nih.gov/pubmed/37118497
http://dx.doi.org/10.1038/s43587-022-00278-w

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