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CSF tau phosphorylation occupancies at T217 and T205 represent improved biomarkers of amyloid and tau pathology in Alzheimer’s disease
Cerebrospinal fluid (CSF) amyloid-β peptide (Aβ)42/Aβ40 and the concentration of tau phosphorylated at site 181 (p-tau181) are well-established biomarkers of Alzheimer’s disease (AD). The present study used mass spectrometry to measure concentrations of nine phosphorylated and five nonphosphorylated...
Autores principales: | Barthélemy, Nicolas R., Saef, Benjamin, Li, Yan, Gordon, Brian A., He, Yingxin, Horie, Kanta, Stomrud, Erik, Salvadó, Gemma, Janelidze, Shorena, Sato, Chihiro, Ovod, Vitaliy, Henson, Rachel L., Fagan, Anne M., Benzinger, Tammie L. S., Xiong, Chengjie, Morris, John C., Hansson, Oskar, Bateman, Randall J., Schindler, Suzanne E. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154225/ https://www.ncbi.nlm.nih.gov/pubmed/37117788 http://dx.doi.org/10.1038/s43587-023-00380-7 |
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