Aging is associated with a systemic length-associated transcriptome imbalance

Aging is among the most important risk factors for morbidity and mortality. To contribute toward a molecular understanding of aging, we analyzed age-resolved transcriptomic data from multiple studies. Here, we show that transcript length alone explains most transcriptional changes observed with agin...

Descripción completa

Detalles Bibliográficos
Autores principales: Stoeger, Thomas, Grant, Rogan A., McQuattie-Pimentel, Alexandra C., Anekalla, Kishore R., Liu, Sophia S., Tejedor-Navarro, Heliodoro, Singer, Benjamin D., Abdala-Valencia, Hiam, Schwake, Michael, Tetreault, Marie-Pier, Perlman, Harris, Balch, William E., Chandel, Navdeep S., Ridge, Karen M., Sznajder, Jacob I., Morimoto, Richard I., Misharin, Alexander V., Budinger, G. R. Scott, Nunes Amaral, Luis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Analysis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154227/
https://www.ncbi.nlm.nih.gov/pubmed/37118543
http://dx.doi.org/10.1038/s43587-022-00317-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154227/
https://www.ncbi.nlm.nih.gov/pubmed/37118543
http://dx.doi.org/10.1038/s43587-022-00317-6

Ejemplares similares