G-CSF drives autoinflammation in APLAID

Missense mutations in PLCG2 can cause autoinflammation with phospholipase C gamma 2-associated antibody deficiency and immune dysregulation (APLAID). Here, we generated a mouse model carrying an APLAID mutation (p.Ser707Tyr) and found that inflammatory infiltrates in the skin and lungs were only par...

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Detalles Bibliográficos
Autores principales: Mulazzani, Elisabeth, Kong, Klara, Aróstegui, Juan I., Ng, Ashley P., Ranathunga, Nishika, Abeysekera, Waruni, Garnham, Alexandra L., Ng, Sze-Ling, Baker, Paul J., Jackson, Jacob T., Lich, John D., Hibbs, Margaret L., Wicks, Ian P., Louis, Cynthia, Masters, Seth L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154231/
https://www.ncbi.nlm.nih.gov/pubmed/36997670
http://dx.doi.org/10.1038/s41590-023-01473-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154231/
https://www.ncbi.nlm.nih.gov/pubmed/36997670
http://dx.doi.org/10.1038/s41590-023-01473-6

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