Immune system-wide Mendelian randomization and triangulation analyses support autoimmunity as a modifiable component in dementia-causing diseases

Immune system and blood–brain barrier dysfunction are implicated in the development of Alzheimer’s and other dementia-causing diseases, but their causal role remains unknown. We performed Mendelian randomization for 1,827 immune system- and blood–brain barrier-related biomarkers and identified 127 p...

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Detalles Bibliográficos
Autores principales: Lindbohm, Joni V., Mars, Nina, Sipilä, Pyry N., Singh-Manoux, Archana, Runz, Heiko, Livingston, Gill, Seshadri, Sudha, Xavier, Ramnik, Hingorani, Aroon D., Ripatti, Samuli, Kivimäki, Mika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154235/
https://www.ncbi.nlm.nih.gov/pubmed/37118290
http://dx.doi.org/10.1038/s43587-022-00293-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154235/
https://www.ncbi.nlm.nih.gov/pubmed/37118290
http://dx.doi.org/10.1038/s43587-022-00293-x

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