Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity

Changes in splicing fidelity are associated with loss of homeostasis and aging, yet only a handful of splicing factors have been shown to be causally required to promote longevity, and the underlying mechanisms and downstream targets in these paradigms remain elusive. Surprisingly, we found a hypomo...

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Detalles Bibliográficos
Autores principales: Huang, Wenming, Kew, Chun, Fernandes, Stephanie de Alcantara, Löhrke, Anna, Han, Lynn, Demetriades, Constantinos, Antebi, Adam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154236/
https://www.ncbi.nlm.nih.gov/pubmed/37118503
http://dx.doi.org/10.1038/s43587-022-00275-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154236/
https://www.ncbi.nlm.nih.gov/pubmed/37118503
http://dx.doi.org/10.1038/s43587-022-00275-z

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