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Decreased spliceosome fidelity and egl-8 intron retention inhibit mTORC1 signaling to promote longevity
Changes in splicing fidelity are associated with loss of homeostasis and aging, yet only a handful of splicing factors have been shown to be causally required to promote longevity, and the underlying mechanisms and downstream targets in these paradigms remain elusive. Surprisingly, we found a hypomo...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group US
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154236/ https://www.ncbi.nlm.nih.gov/pubmed/37118503 http://dx.doi.org/10.1038/s43587-022-00275-z |