Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin

Pharmacological attenuation of mTOR presents a promising route for delay of age-related disease. Here we show that treatment of Drosophila with the mTOR inhibitor rapamycin extends lifespan in females, but not in males. Female-specific, age-related gut pathology is markedly slowed by rapamycin treat...

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Detalles Bibliográficos
Autores principales: Regan, Jennifer C., Lu, Yu-Xuan, Ureña, Enric, Meilenbrock, Ralf L., Catterson, James H., Kißler, Disna, Fröhlich, Jenny, Funk, Emilie, Partridge, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154239/
https://www.ncbi.nlm.nih.gov/pubmed/37118538
http://dx.doi.org/10.1038/s43587-022-00308-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154239/
https://www.ncbi.nlm.nih.gov/pubmed/37118538
http://dx.doi.org/10.1038/s43587-022-00308-7

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