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Selective neurodegeneration generated by intravenous α‐synuclein pre‐formed fibril administration is not associated with endogenous α‐synuclein levels in the rat brain

Selective loss of discrete neuronal populations is a prominent feature of many neurodegenerative conditions, but the molecular basis of this is poorly understood. A central role of α‐synuclein in the selective neurodegeneration of Parkinson's disease has been speculated, as its level of express...

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Detalles Bibliográficos
Autores principales: Kuan, Wei‐Li, Alfaidi, Maha, Horne, Catherine B., Vallin, Benjamin, Fox, Sarah, Fazal, Shaline V., Williams‐Gray, Caroline H., Barker, Roger A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154377/
https://www.ncbi.nlm.nih.gov/pubmed/36321260
http://dx.doi.org/10.1111/bpa.13128