Cargando…
Selective neurodegeneration generated by intravenous α‐synuclein pre‐formed fibril administration is not associated with endogenous α‐synuclein levels in the rat brain
Selective loss of discrete neuronal populations is a prominent feature of many neurodegenerative conditions, but the molecular basis of this is poorly understood. A central role of α‐synuclein in the selective neurodegeneration of Parkinson's disease has been speculated, as its level of express...
Autores principales: | Kuan, Wei‐Li, Alfaidi, Maha, Horne, Catherine B., Vallin, Benjamin, Fox, Sarah, Fazal, Shaline V., Williams‐Gray, Caroline H., Barker, Roger A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154377/ https://www.ncbi.nlm.nih.gov/pubmed/36321260 http://dx.doi.org/10.1111/bpa.13128 |
Ejemplares similares
-
Hyperosmotic stress induces cell-dependent aggregation of α-synuclein
por: Fragniere, Alexandra M. C., et al.
Publicado: (2019) -
Quaternary structure of patient-homogenate amplified α-synuclein fibrils modulates seeding of endogenous α-synuclein
por: Frieg, Benedikt, et al.
Publicado: (2022) -
Oral and intravenous transmission of α-synuclein fibrils to mice
por: Lohmann, Stephanie, et al.
Publicado: (2019) -
Neurodegeneration and the ordered assembly of α-synuclein
por: Spillantini, Maria Grazia, et al.
Publicado: (2017) -
α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
por: Tran, Hien T., et al.
Publicado: (2014)