Targeting TACC3 represents a novel vulnerability in highly aggressive breast cancers with centrosome amplification

Centrosome amplification (CA) is a hallmark of cancer that is strongly associated with highly aggressive disease and worse clinical outcome. Clustering extra centrosomes is a major coping mechanism required for faithful mitosis of cancer cells with CA that would otherwise undergo mitotic catastrophe...

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Detalles Bibliográficos
Autores principales: Saatci, Ozge, Akbulut, Ozge, Cetin, Metin, Sikirzhytski, Vitali, Uner, Meral, Lengerli, Deniz, O’Quinn, Elizabeth C., Romeo, Martin J., Caliskan, Burcu, Banoglu, Erden, Aksoy, Sercan, Uner, Aysegul, Sahin, Ozgur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154422/
https://www.ncbi.nlm.nih.gov/pubmed/36864125
http://dx.doi.org/10.1038/s41418-023-01140-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154422/
https://www.ncbi.nlm.nih.gov/pubmed/36864125
http://dx.doi.org/10.1038/s41418-023-01140-1

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