Targeting polymerase θ impairs tumorigenesis and enhances radiosensitivity in lung adenocarcinoma

Radioresistance remains a major obstacle to efficacious radiotherapy in non–small‐cell lung cancer (NSCLC). DNA replication proteins are novel targets for radiosensitizers. POLQ is a DNA polymerase involved in DNA damage response and repair. We found that POLQ is overexpressed in NSCLC and is clinic...

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Detalles Bibliográficos
Autores principales: Rao, Xinrui, Xing, Biyuan, Wu, Zilong, Bin, Yawen, Chen, Yunshang, Xu, Yingzhuo, Zhou, Dong, Zhou, Xiaoshu, Wu, Chuangyan, Ye, Wang, Chen, Weibin, Wang, Geng, Zhang, Sheng, Dong, Xiaorong, Meng, Rui, Wu, Gang, Zhou, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154803/
https://www.ncbi.nlm.nih.gov/pubmed/36642785
http://dx.doi.org/10.1111/cas.15727

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10154803/
https://www.ncbi.nlm.nih.gov/pubmed/36642785
http://dx.doi.org/10.1111/cas.15727

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