Low TCR Binding Strength Results in Increased Progenitor-like CD8(+) Tumor-Infiltrating Lymphocytes

T-cell receptor (TCR) binding strength to peptide-MHC antigen complex influences numerous T-cell functions. However, the vast diversity of a polyclonal T-cell repertoire for even a single antigen greatly increases the complexity of studying the impact of TCR affinity on T-cell function. Here, we det...

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Detalles Bibliográficos
Autores principales: Hay, Zachary L.Z., Knapp, Jennifer R., Magallon, Roman E., O'Connor, Brian P., Slansky, Jill E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10155039/
https://www.ncbi.nlm.nih.gov/pubmed/36787375
http://dx.doi.org/10.1158/2326-6066.CIR-22-0761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10155039/
https://www.ncbi.nlm.nih.gov/pubmed/36787375
http://dx.doi.org/10.1158/2326-6066.CIR-22-0761

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