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Development of Cationic Lipid LAH4-L1 siRNA Complexes for Focused Ultrasound Enhanced Tumor Uptake

[Image: see text] RNAi has considerable potential as a cancer therapeutic approach, but effective and efficient delivery of short interfering RNA (siRNA) to tumors remains a major hurdle. It remains a challenge to prepare a functional siRNA complex, target enough dose to the tumor, and stimulate its...

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Detalles Bibliográficos
Autores principales: Abuhelal, Shahd, Centelles, Miguel N., Wright, Michael, Mason, A. James, Thanou, Maya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10155207/
https://www.ncbi.nlm.nih.gov/pubmed/36989421
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00909