Cargando…

Loss of Ufl1/Ufbp1 in hepatocytes promotes liver pathological damage and carcinogenesis through activating mTOR signaling

BACKGROUND: Ufm1-specific ligase 1 (Ufl1) and Ufm1-binding protein 1 (Ufbp1), as putative targets of ubiquitin-fold modifier 1 (Ufm1), have been implicated in several pathogenesis-related signaling pathways. However, little is known about their functional roles in liver disease. METHODS: Hepatocyte-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Fanghui, Sheng, Le, Zhou, Tianci, Yan, Li, Loveless, Reid, Li, Honglin, Teng, Yong, Cai, Yafei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10155312/ https://www.ncbi.nlm.nih.gov/pubmed/37131258 http://dx.doi.org/10.1186/s13046-023-02681-6

Ejemplares similares

UFL1, a UFMylation E3 ligase, plays a crucial role in multiple cellular stress responses
por: Jiang, Qiang, et al.
Publicado: (2023)

Ufbp1, a Key Player of Ufm1 Conjugation System, Protects Against Ketosis-Induced Liver Injury via Suppressing Smad3 Activation
por: Chen, Fanghui, et al.
Publicado: (2021)

UFBP1, a Key Component of the Ufm1 Conjugation System, Is Essential for Ufmylation-Mediated Regulation of Erythroid Development
por: Cai, Yafei, et al.
Publicado: (2015)

UFL1 promotes histone H4 ufmylation and ATM activation
por: Qin, Bo, et al.
Publicado: (2019)

Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR
por: Zhu, Huabin, et al.
Publicado: (2019)

Ufmylation of UFBP1 Is Dispensable for Endoplasmic Reticulum Stress Response, Embryonic Development, and Cardiac and Intestinal Homeostasis
por: Tandra, Varsha, et al.
Publicado: (2023)

Ufl1 deficiency causes skin pigmentation by up-regulation of Endothelin-1
por: Wang, Ke, et al.
Publicado: (2022)

UFL1 promotes antiviral immune response by maintaining STING stability independent of UFMylation
por: Tao, Yijie, et al.
Publicado: (2022)

UFL1 Alleviates Lipopolysaccharide-Induced Cell Damage and Inflammation via Regulation of the TLR4/NF-κB Pathway in Bovine Mammary Epithelial Cells
por: Li, Chengmin, et al.
Publicado: (2019)

Ufmylation on UFBP1 alleviates non-alcoholic fatty liver disease by modulating hepatic endoplasmic reticulum stress
por: Mao, Ziming, et al.
Publicado: (2023)

UFL1 Alleviates LPS-Induced Apoptosis by Regulating the NF-κB Signaling Pathway in Bovine Ovarian Granulosa Cells
por: Wang, Xinling, et al.
Publicado: (2020)

Protocol for the assessment of mTOR activity in mouse primary hepatocytes
por: Plata-Gómez, Ana Belén, et al.
Publicado: (2021)

Inhibition of mTOR Reduces Anal Carcinogenesis in Transgenic Mouse Model
por: Sun, Zhi-Jun, et al.
Publicado: (2013)

Cyclopamine and Rapamycin Synergistically Inhibit mTOR Signalling in Mouse Hepatocytes, Revealing an Interaction of Hedgehog and mTor Signalling in the Liver
por: Spormann, Luise, et al.
Publicado: (2020)

Ubiquitin Fold Modifier 1 (UFM1) and Its Target UFBP1 Protect Pancreatic Beta Cells from ER Stress-Induced Apoptosis
por: Lemaire, Katleen, et al.
Publicado: (2011)

mTOR Complex 1 Implicated in Aphid/Buchnera Host/Symbiont Integration
por: James, Edward B., et al.
Publicado: (2018)

Human hepatocyte carcinogenesis
por: SHIRAHA, HIDENORI, et al.
Publicado: (2013)

Hepatocyte Paraffin 1 Immunoreactivity in Early Colon Carcinogenesis
por: Nemolato, Sonia, et al.
Publicado: (2009)

ANLN promotes carcinogenesis in oral cancer by regulating the PI3K/mTOR signaling pathway
por: Wang, Bing, et al.
Publicado: (2021)

Development of Corn Starch-Neusilin UFL2 Conjugate as Tablet Superdisintegrant: Formulation and Evaluation of Fast Disintegrating Tablets
por: Juneja, Prateek, et al.
Publicado: (2014)

Zinc-finger protein CXXC5 promotes breast carcinogenesis by regulating the TSC1/mTOR signaling pathway
por: Wang, Wenjuan, et al.
Publicado: (2022)

PI3K/Akt/mTOR Signaling Pathway and the Biphasic Effect of Arsenic in Carcinogenesis
por: Chen, Qiao Yi, et al.
Publicado: (2018)

mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer
por: Gao, Wei, et al.
Publicado: (2012)

Mitochondrial IRG1 traps MCL-1 to induce hepatocyte apoptosis and promote carcinogenesis
por: Zhang, Liyuan, et al.
Publicado: (2023)

Propionate promotes gluconeogenesis by regulating mechanistic target of rapamycin (mTOR) pathway in calf hepatocytes
por: Wang, Guo Yan, et al.
Publicado: (2023)

AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1
por: Umanah, George K. E., et al.
Publicado: (2022)

Molecular damage in cancer: an argument for mTOR-driven aging
por: Blagosklonny, Mikhail V.
Publicado: (2011)

mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges
por: Zou, Zhilin, et al.
Publicado: (2020)

Regulation of CHK1 by mTOR contributes to the evasion of DNA damage barrier of cancer cells
por: Zhou, Xinhui, et al.
Publicado: (2017)

IDO1 involvement in mTOR pathway: a molecular mechanism of resistance to mTOR targeting in medulloblastoma
por: Folgiero, Valentina, et al.
Publicado: (2016)

mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy
por: Tian, Tian, et al.
Publicado: (2019)

CDK5RAP3, a Novel Nucleoplasmic Shuttle, Deeply Regulates HSF1-Mediated Heat Stress Response and Protects Mammary Epithelial Cells from Heat Injury
por: Shen, Yangyang, et al.
Publicado: (2020)

Dendrite pathology and neurodegeneration: focus on mTOR
por: Di Polo, Adriana
Publicado: (2015)

Expression of mTOR in normal and pathological conditions
por: Marques-Ramos, A, et al.
Publicado: (2023)

Long noncoding RNA BFAL1 mediates enterotoxigenic Bacteroides fragilis-related carcinogenesis in colorectal cancer via the RHEB/mTOR pathway
por: Bao, Yujie, et al.
Publicado: (2019)

Rapamycin Reduced Ischemic Brain Damage in Diabetic Animals Is Associated with Suppressions of mTOR and ERK1/2 Signaling
por: Liu, Ping, et al.
Publicado: (2016)

mTOR, AMBRA1, and autophagy: An intricate relationship
por: Nazio, Francesca, et al.
Publicado: (2013)

Myelination and mTOR
por: Figlia, Gianluca, et al.
Publicado: (2017)

Role of Hepatocyte‐Derived Osteopontin in Liver Carcinogenesis
por: Desert, Romain, et al.
Publicado: (2021)

Expression of TGF-β1/mTOR signaling pathway in pathological scar fibroblasts
por: Zhai, Xiao-Xiang, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_upeevkbda9k7f60g21mb03jkiu