Cargando…

The G51D SNCA mutation generates a slowly progressive α-synuclein strain in early-onset Parkinson’s disease

Unique strains of α-synuclein aggregates have been postulated to underlie the spectrum of clinical and pathological presentations seen across the synucleinopathies. Whereas multiple system atrophy (MSA) is associated with a predominance of oligodendroglial α-synuclein inclusions, α-synuclein aggrega...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lau, Heather H. C., Martinez-Valbuena, Ivan, So, Raphaella W. L., Mehra, Surabhi, Silver, Nicholas R. G., Mao, Alison, Stuart, Erica, Schmitt-Ulms, Cian, Hyman, Bradley T., Ingelsson, Martin, Kovacs, Gabor G., Watts, Joel C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10155462/ https://www.ncbi.nlm.nih.gov/pubmed/37138318 http://dx.doi.org/10.1186/s40478-023-01570-5

Ejemplares similares

α-Synuclein Strains Target Distinct Brain Regions and Cell Types
por: Lau, Angus, et al.
Publicado: (2019)

Neuronal SNCA transcription during Lewy body formation
por: Kon, Tomoya, et al.
Publicado: (2023)

Alpha-synuclein seeding shows a wide heterogeneity in multiple system atrophy
por: Martinez-Valbuena, Ivan, et al.
Publicado: (2022)

Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation
por: Kiely, Aoife P., et al.
Publicado: (2015)

Salivary total α-synuclein, oligomeric α-synuclein and SNCA variants in Parkinson’s disease patients
por: Kang, Wenyan, et al.
Publicado: (2016)

Genetic Variants of the α-Synuclein Gene SNCA Are Associated with Multiple System Atrophy
por: Al-Chalabi, Ammar, et al.
Publicado: (2009)

Snca-GFP Knock-In Mice Allows Tracking the Endogenous α-Synuclein in Action
por: Er, Safak
Publicado: (2021)

New SNCA mutation and structures of α-synuclein filaments from juvenile-onset synucleinopathy
por: Yang, Yang, et al.
Publicado: (2023)

SNCA genetic lowering reveals differential cognitive function of alpha-synuclein dependent on sex
por: Brown, Jennifer L., et al.
Publicado: (2022)

A novel autophagy modulator 6-Bio ameliorates SNCA/α-synuclein toxicity
por: Suresh, S. N., et al.
Publicado: (2017)

Network Analysis Implicates Alpha-Synuclein (Snca) in the Regulation of Ovariectomy-Induced Bone Loss
por: Calabrese, Gina, et al.
Publicado: (2016)

Targeted attenuation of elevated histone marks at SNCA alleviates α‐synuclein in Parkinson's disease
por: Guhathakurta, Subhrangshu, et al.
Publicado: (2021)

The Impact of SNCA Variations and Its Product Alpha-Synuclein on Non-Motor Features of Parkinson’s Disease
por: Magistrelli, Luca, et al.
Publicado: (2021)

Linking the phenotype of SNCA Triplication with PET-MRI imaging pattern and alpha-synuclein CSF seeding
por: Wurster, Isabel, et al.
Publicado: (2022)

Regulation of Αlpha-Synuclein Gene (SNCA) by Epigenetic Modifier TET1 in Parkinson Disease
por: Guhathakurta, Subhrangshu, et al.
Publicado: (2022)

Alpha‐synuclein mRNA isoform formation and translation affected by polymorphism in the human SNCA 3ʹUTR
por: Barrie, Elizabeth S., et al.
Publicado: (2018)

Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models
por: Prieto Huarcaya, Susy, et al.
Publicado: (2022)

Slowly, slowly in the wind /
por: Highsmith, Patricia, 1921-1995
Publicado: (1981)

Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human α-synuclein in transgenic mouse brain
por: Cronin, Kenneth D., et al.
Publicado: (2009)

SNCA Triplication Parkinson's Patient's iPSC-derived DA Neurons Accumulate α-Synuclein and Are Susceptible to Oxidative Stress
por: Byers, Blake, et al.
Publicado: (2011)

Disease-Specific α-Synuclein Seeding in Lewy Body Disease and Multiple System Atrophy Are Preserved in Formaldehyde-Fixed Paraffin-Embedded Human Brain
por: Kim, Ain, et al.
Publicado: (2023)

The SNCA-Rep1 Polymorphic Locus: Association with the Risk of Parkinson’s Disease and SNCA Gene Methylation
por: Iakovenko, E. V., et al.
Publicado: (2020)

Aβ43 aggregates exhibit enhanced prion-like seeding activity in mice
por: Ruiz-Riquelme, Alejandro, et al.
Publicado: (2021)

A novel resource for studying function and dysfunction of α-synuclein: mouse lines for modulation of endogenous Snca gene expression
por: Ninkina, Natalia, et al.
Publicado: (2015)

α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson’s disease and multiple system atrophy?
por: Kiely, Aoife P., et al.
Publicado: (2013)

Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells
por: Oliveira, L M A, et al.
Publicado: (2015)

Piperine promotes autophagy flux by P2RX4 activation in SNCA/α-synuclein-induced Parkinson disease model
por: Li, Ruolin, et al.
Publicado: (2021)

α‐Synuclein antisense transcript SNCA‐AS1 regulates synapses‐ and aging‐related genes suggesting its implication in Parkinson's disease
por: Rey, Federica, et al.
Publicado: (2021)

SNCA-AS1 in aging and Parkinson’s disease
por: Carelli, Stephana, et al.
Publicado: (2022)

Structural and Functional Insights into α-Synuclein Fibril Polymorphism
por: Mehra, Surabhi, et al.
Publicado: (2021)

Generation of two human induced pluripotent stem cell lines (iPSCs) with mutations of the α-synuclein (SNCA) gene associated with Parkinson’s disease; the A53T mutation (LCSBi003) and a triplication of the SNCA gene (LCSBi007)
por: Novak, Gabriela, et al.
Publicado: (2021)

Immunisation with UB-312 in the Thy1SNCA mouse prevents motor performance deficits and oligomeric α-synuclein accumulation in the brain and gut
por: Nimmo, Jacqui T., et al.
Publicado: (2021)

Eat Slowly
Publicado: (1895)

Hastening Slowly
Publicado: (1890)

Eat Slowly
Publicado: (1871)

Striatal-Inoculation of α-Synuclein Preformed Fibrils Aggravated the Phenotypes of REM Sleep without Atonia in A53T BAC-SNCA Transgenic Mice
por: Okuda, Shinya, et al.
Publicado: (2022)

Evaluation of the Role of SNCA Variants in Survival without Neurological Disease
por: Heckman, Michael G., et al.
Publicado: (2012)

Prion-like propagation of β-amyloid aggregates in the absence of APP overexpression
por: Ruiz-Riquelme, Alejandro, et al.
Publicado: (2018)

Alpha‐synuclein dynamics in induced pluripotent stem cell‐derived dopaminergic neurons from a Parkinson’s disease patient (PARK4) with SNCA triplication
por: Fukusumi, Hayato, et al.
Publicado: (2021)

Variants in the SNCA Locus Are Associated With the Progression of Parkinson's Disease
por: Luo, Ningdi, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_vos9nb6ue5tqpqlepvigd7p4fk