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LZY3016, a novel geldanamycin derivative, inhibits tumor growth in an MDA-MB-231 xenograft model
A novel geldanamycin derivative LZY3016 was synthesized as an antitumor agent. Compound LZY3016 exhibited potent anti-proliferation activity toward MDA-MB-231 (IC(50) = 0.06 μM), which was more effective than positive drug 17-AAG. In vivo hepatotoxicity assay displayed that serum AST/ALT levels in L...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10155491/ https://www.ncbi.nlm.nih.gov/pubmed/37152572 http://dx.doi.org/10.1039/d3ra02131a |