Synthesis and identification of new sacubitril derivatives as lead compounds for antibacterial, antifungal and antitubercular (TB) activities against dormant tuberculosis

We identified twenty-two new sacubitril derivatives (5a–v) as lead compounds for various biologically active targets. These compounds were synthesized by reacting an intermediate compound (2R,4S)-5-([1,1′-biphenyl]-4-yl)-4-(amino)-2-methylpentanoic acid ethyl ester hydrochloride with respective carb...

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Detalles Bibliográficos
Autores principales: Bhargavi, Dodda, Konduri, Srihari, Prashanth, Jyothi, Pulipati, Sowjanya, Praneeth, K. K., Sireesha, Malladi, Rao, Koya Prabhakara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10155492/
https://www.ncbi.nlm.nih.gov/pubmed/37152580
http://dx.doi.org/10.1039/d3ra00713h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10155492/
https://www.ncbi.nlm.nih.gov/pubmed/37152580
http://dx.doi.org/10.1039/d3ra00713h

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