Divergent acute versus prolonged pharmacological GLP-1R responses in adult β cell–specific β-arrestin 2 knockout mice

The glucagon-like peptide-1 receptor (GLP-1R) is a major type 2 diabetes therapeutic target. Stimulated GLP-1Rs are rapidly desensitized by β-arrestins, scaffolding proteins that not only terminate G protein interactions but also act as independent signaling mediators. Here, we have assessed in vivo...

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Detalles Bibliográficos
Autores principales: Bitsi, Stavroula, El Eid, Liliane, Manchanda, Yusman, Oqua, Affiong I., Mohamed, Nimco, Hansen, Ben, Suba, Kinga, Rutter, Guy A., Salem, Victoria, Jones, Ben, Tomas, Alejandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156113/
https://www.ncbi.nlm.nih.gov/pubmed/37134170
http://dx.doi.org/10.1126/sciadv.adf7737

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156113/
https://www.ncbi.nlm.nih.gov/pubmed/37134170
http://dx.doi.org/10.1126/sciadv.adf7737

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