Cargando…

Visualizing the disordered nuclear transport machinery in situ

The approximately 120 MDa mammalian nuclear pore complex (NPC) acts as a gatekeeper for the transport between the nucleus and cytosol(1). The central channel of the NPC is filled with hundreds of intrinsically disordered proteins (IDPs) called FG-nucleoporins (FG-NUPs)(2,3). Although the structure o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Miao, Heidari, Maziar, Mikhaleva, Sofya, Tan, Piau Siong, Mingu, Sara, Ruan, Hao, Reinkemeier, Christopher D., Obarska-Kosinska, Agnieszka, Siggel, Marc, Beck, Martin, Hummer, Gerhard, Lemke, Edward A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156602/ https://www.ncbi.nlm.nih.gov/pubmed/37100914 http://dx.doi.org/10.1038/s41586-023-05990-0

Ejemplares similares

Two Differential Binding Mechanisms of FG-Nucleoporins and Nuclear Transport Receptors
por: Tan, Piau Siong, et al.
Publicado: (2018)

Dynamic cluster formation determines viscosity and diffusion in dense protein solutions
por: von Bülow, Sören, et al.
Publicado: (2019)

PepComposer: computational design of peptides binding to a given protein surface
por: Obarska-Kosinska, Agnieszka, et al.
Publicado: (2016)

FAM134B-RHD Protein Clustering Drives Spontaneous Budding of Asymmetric Membranes
por: Siggel, Marc, et al.
Publicado: (2021)

Unwrapping NPT Simulations to Calculate Diffusion Coefficients
por: Bullerjahn, Jakob Tómas, et al.
Publicado: (2023)

Corrigendum to “HsdR Subunit of the Type I Restriction-Modification Enzyme EcoR124I: Biophysical Characterisation and Structural Modelling” [J. Mol. Biol. 376(2) 2008 Feb 15: 438–452.]()
por: Obarska-Kosinska, Agnieszka, et al.
Publicado: (2020)

Spatiotemporal Regulation of Nuclear Transport Machinery and Microtubule Organization
por: Okada, Naoyuki, et al.
Publicado: (2015)

Dual film-like organelles enable spatial separation of orthogonal eukaryotic translation
por: Reinkemeier, Christopher D., et al.
Publicado: (2021)

Membrane curvature sensing and stabilization by the autophagic LC3 lipidation machinery
por: Jensen, Liv E., et al.
Publicado: (2022)

Viral Appropriation: Laying Claim to Host Nuclear Transport Machinery
por: Tessier, Tanner M., et al.
Publicado: (2019)

HsdR Subunit of the Type I Restriction-Modification Enzyme EcoR124I: Biophysical Characterisation and Structural Modelling
por: Obarska-Kosinska, Agnieszka, et al.
Publicado: (2008)

Mechanism‐Dependent Modulation of Ultrafast Interfacial Water Dynamics in Intrinsically Disordered Protein Complexes
por: Chowdhury, Aritra, et al.
Publicado: (2019)

Function of the Nuclear Transport Machinery in Maintaining the Distinctive Compositions of the Nucleus and Cytoplasm
por: Stewart, Murray
Publicado: (2022)

Structure and in situ organisation of the Pyrococcus furiosus archaellum machinery
por: Daum, Bertram, et al.
Publicado: (2017)

Monomeric Huntingtin Exon 1 Has Similar Overall Structural Features for Wild-Type and Pathological Polyglutamine Lengths
por: Warner, John B., et al.
Publicado: (2017)

In situ structural analysis of the human nuclear pore complex
por: von Appen, Alexander, et al.
Publicado: (2015)

Co-translational binding of importins to nascent proteins
por: Seidel, Maximilian, et al.
Publicado: (2023)

Hepatitis C virus and host cell nuclear transport machinery: a clandestine affair
por: Bonamassa, Barbara, et al.
Publicado: (2015)

Experimental Applications of in situ Liver Perfusion Machinery for the Study of Liver Disease
por: Choi, Won-Mook, et al.
Publicado: (2019)

Inducible Genetic Code Expansion in Eukaryotes
por: Koehler, Christine, et al.
Publicado: (2020)

The structure of M.EcoKI Type I DNA methyltransferase with a DNA mimic antirestriction protein
por: Kennaway, Christopher K., et al.
Publicado: (2009)

In situ structural analysis reveals membrane shape transitions during autophagosome formation
por: Bieber, Anna, et al.
Publicado: (2022)

Mechanism of conditional partner selectivity in MITF/TFE family transcription factors with a conserved coiled coil stammer motif
por: Pogenberg, Vivian, et al.
Publicado: (2020)

Membrane fusion and drug delivery with carbon nanotube porins
por: Ho, Nga T., et al.
Publicado: (2021)

Debugging Eukaryotic Genetic Code Expansion for Site‐Specific Click‐PAINT Super‐Resolution Microscopy
por: Nikić, Ivana, et al.
Publicado: (2016)

In situ architecture of the algal nuclear pore complex
por: Mosalaganti, Shyamal, et al.
Publicado: (2018)

In situ cryo-electron tomography reveals local cellular machineries for axon branch development
por: Nedozralova, Hana, et al.
Publicado: (2022)

A COG in the retrograde transport machinery
por: Short, Ben
Publicado: (2011)

Phosphatidylcholine: Greasing the Cholesterol Transport Machinery
por: Lagace, Thomas A.
Publicado: (2016)

Nuclear-encoded factors associated with the chloroplast transcription machinery of higher plants
por: Yu, Qing-Bo, et al.
Publicado: (2014)

DNAJC17 is localized in nuclear speckles and interacts with splicing machinery components
por: Pascarella, A., et al.
Publicado: (2018)

Chromatin Compaction by Small RNAs and the Nuclear RNAi Machinery in C. elegans
por: Fields, Brandon D., et al.
Publicado: (2019)

Floppy but not sloppy: Interaction mechanism of FG-nucleoporins and nuclear transport receptors
por: Aramburu, Iker Valle, et al.
Publicado: (2017)

Machinery
Publicado: (1883)

Integrity of SRP RNA is ensured by La and the nuclear RNA quality control machinery
por: Leung, Eileen, et al.
Publicado: (2014)

Cytoplasmic Dynamics of the General Nuclear Import Machinery in Apically Growing Syncytial Cells
por: Etxebeste, Oier, et al.
Publicado: (2013)

Arabidopsis TCP Transcription Factors Interact with the SUMO Conjugating Machinery in Nuclear Foci
por: Mazur, Magdalena J., et al.
Publicado: (2017)

The ESCRT machinery directs quality control over inner nuclear membrane architecture
por: Shankar, Raakhee, et al.
Publicado: (2022)

Molecular phylogenetics and comparative modeling of HEN1, a methyltransferase involved in plant microRNA biogenesis
por: Tkaczuk, Karolina L, et al.
Publicado: (2006)

Cellular and Subcellular Phosphate Transport Machinery in Plants
por: Srivastava, Sudhakar, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_tmbt271mtis0jhuv2q7q0219os