Primary cells from patients with adult T cell leukemia/lymphoma depend on HTLV-1 Tax expression for NF-κB activation and survival

Adult T cell leukemia/lymphoma (ATL) is an aggressive malignancy secondary to chronic infection with human T cell leukemia virus type 1 (HTLV-1). The viral oncoprotein Tax initiates T cell transformation through activation of critical cellular pathways, including NF-κB. Unexpectedly, Tax protein is...

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Detalles Bibliográficos
Autores principales: Hleihel, Rita, Skayneh, Hala, de Thé, Hugues, Hermine, Olivier, Bazarbachi, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156663/
https://www.ncbi.nlm.nih.gov/pubmed/37137914
http://dx.doi.org/10.1038/s41408-023-00841-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156663/
https://www.ncbi.nlm.nih.gov/pubmed/37137914
http://dx.doi.org/10.1038/s41408-023-00841-7

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