Cargando…

Primary cells from patients with adult T cell leukemia/lymphoma depend on HTLV-1 Tax expression for NF-κB activation and survival

Adult T cell leukemia/lymphoma (ATL) is an aggressive malignancy secondary to chronic infection with human T cell leukemia virus type 1 (HTLV-1). The viral oncoprotein Tax initiates T cell transformation through activation of critical cellular pathways, including NF-κB. Unexpectedly, Tax protein is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hleihel, Rita, Skayneh, Hala, de Thé, Hugues, Hermine, Olivier, Bazarbachi, Ali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156663/ https://www.ncbi.nlm.nih.gov/pubmed/37137914 http://dx.doi.org/10.1038/s41408-023-00841-7

Ejemplares similares

In vivo antagonistic role of the Human T-Cell Leukemia Virus Type 1 regulatory proteins Tax and HBZ
por: Akkouche, Abdou, et al.
Publicado: (2021)

Can we cure HTLV-I associated Adult T cell Leukemia Lymphoma?
por: Bazarbachi, Ali, et al.
Publicado: (2011)

A Critical Review of Animal Models Used in Acute Myeloid Leukemia Pathophysiology
por: Skayneh, Hala, et al.
Publicado: (2019)

The HTLV-1 oncoprotein Tax is modified by the ubiquitin related modifier 1 (Urm1)
por: Hleihel, Rita, et al.
Publicado: (2018)

Low levels of HTLV-2 Tax conjugation to ubiquitin and SUMO do not impede Tax-mediated activation of NF-κB
por: Journo, Chloé, et al.
Publicado: (2014)

Adult T-cell leukemia/lymphoma in a Caucasian patient after sexual transmission of HTLV-1
por: Sibon, David, et al.
Publicado: (2015)

HTLV-1 Tax-activated NF-κB is involved in both cell growth and death
por: Mizuguchi, Mariko, et al.
Publicado: (2014)

Interplay between innate immunity and the viral oncoproteins Tax and HBZ in the pathogenesis and therapeutic response of HTLV-1 associated adult T cell leukemia
por: El Hajj, Hiba, et al.
Publicado: (2022)

Ras signaling contributes to survival of human T-cell leukemia/lymphoma virus type 1 (HTLV-1) Tax-positive T-cells
por: Stoppa, Giovanna, et al.
Publicado: (2011)

HTLV Deregulation of the NF-κB Pathway: An Update on Tax and Antisense Proteins Role
por: Fochi, Stefania, et al.
Publicado: (2018)

NF-κB and MicroRNA Deregulation Mediated by HTLV-1 Tax and HBZ
por: Fochi, Stefania, et al.
Publicado: (2019)

Deciphering the molecular basis of arsenic/interferon-alpha induced eradication of leukemia initiating cells in adult T cell leukemia
por: El Hajj, Hiba, et al.
Publicado: (2015)

Tax-1 and Tax-2 similarities and differences: focus on post-translational modifications and NF-κB activation
por: Shirinian, Margret, et al.
Publicado: (2013)

The human T-cell leukemia virus type I (HTLV-I) oncoprotein Tax promotes persistent NF-κB activation by blocking the phosphorylation of the adaptor molecule TAX1BP
por: Shembade, Noula, et al.
Publicado: (2011)

HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma—A Tale of Two Proteins: Tax and HBZ
por: Giam, Chou-Zen, et al.
Publicado: (2016)

TRAF3 Is Required for NF-κB Pathway Activation Mediated by HTLV Tax Proteins
por: Fochi, Stefania, et al.
Publicado: (2019)

Controversies in Targeted Therapy of Adult T Cell Leukemia/Lymphoma: ON Target or OFF Target Effects?
por: Nasr, Rihab, et al.
Publicado: (2011)

Ubiquitination and sumoylation of the HTLV-2 Tax-2B protein regulate its NF-κB activity: a comparative study with the HTLV-1 Tax-1 protein
por: Turci, Marco, et al.
Publicado: (2012)

A novel positive feedback-loop between the HTLV-1 oncoprotein Tax and NF-κB activity in T-cells
por: Millen, Sebastian, et al.
Publicado: (2020)

Loss of interleukin-10 activates innate immunity to eradicate adult T-cell leukemia-initiating cells
por: El Hajj, Hiba, et al.
Publicado: (2021)

Novel Treatments of Adult T Cell Leukemia Lymphoma
por: El Hajj, Hiba, et al.
Publicado: (2020)

ATLL introduction: is there a standard of care for treatment of adult T cell Leukemia Lymphoma?
por: Bazarbachi, Ali, et al.
Publicado: (2014)

SQSTM1/p62 regulates HTLV-1 tax mediated NF-κB activation
por: Schwob, Aurélien, et al.
Publicado: (2015)

HTLV-I Tax inhibits innate antiviral signaling via NF-κB-dependent induction of SOCS1
por: Charoenthongtrakul, Soratree, et al.
Publicado: (2011)

Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax Requires CADM1/TSLC1 for Inactivation of the NF-κB Inhibitor A20 and Constitutive NF-κB Signaling
por: Pujari, Rajeshree, et al.
Publicado: (2015)

Predominant role of Tax sumoylation in Tax-induced NF-kB activation in T cells
por: Bonnet, Amandine, et al.
Publicado: (2011)

Coordination of the canonical and noncanonical IKK/NF-κB signaling pathways in HTLV-I Tax-mediated tumorigenesis
por: Fu, Jing, et al.
Publicado: (2011)

The tumour marker Fascin is strongly induced by Tax of HTLV-1 through NF-κB signals in T lymphocytes
por: Kress, Andrea K, et al.
Publicado: (2011)

Regulation of HTLV-1 Tax Stability, Cellular Trafficking and NF-κB Activation by the Ubiquitin-Proteasome Pathway
por: Lavorgna, Alfonso, et al.
Publicado: (2014)

Intragenic recruitment of NF-κB drives splicing modifications upon activation by the oncogene Tax of HTLV-1
por: Ameur, Lamya Ben, et al.
Publicado: (2020)

Tax as a therapeutic target in ATL
por: Dassouki, Zeina, et al.
Publicado: (2015)

Tax as a therapeutic target in ATL
por: Dassouki, Zeina, et al.
Publicado: (2015)

Tax as a therapeutic target in ATL
por: Dassouki, Zeina, et al.
Publicado: (2015)

Future Perspectives on Drug Targeting in Adult T Cell Leukemia-Lymphoma
por: Marino-Merlo, Francesca, et al.
Publicado: (2018)

A Critical Role for IL-17RB Signaling in HTLV-1 Tax-Induced NF-κB Activation and T-Cell Transformation
por: Lavorgna, Alfonso, et al.
Publicado: (2014)

A critical role for IL-17RB signaling in HTLV-1 tax-induced NF-κB activation and T-cell transformation
por: Lavorgna, Alfonso, et al.
Publicado: (2015)

Diagnostic Approaches and Established Treatments for Adult T Cell Leukemia Lymphoma
por: Tsukasaki, Kunihiro, et al.
Publicado: (2020)

HTLV‐1 Tax‐specific memory cytotoxic T lymphocytes in long‐term survivors of aggressive‐type adult T‐cell leukemia/lymphoma
por: Jo, Tatsuro, et al.
Publicado: (2022)

Human T‐cell lymphotropic/leukemia virus type 1 (HTLV‐1) Tax‐specific T‐cell exhaustion in HTLV‐1‐infected individuals
por: Masaki, Ayako, et al.
Publicado: (2018)

The HTLV-1 Tax interactome
por: Boxus, Mathieu, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_nldfcr4peaifdfuvk7b6t7gvmg