mGluR5 PAMs rescue cortical and behavioural defects in a mouse model of CDKL5 deficiency disorder

Cyclin-dependent kinase-like 5 (CDKL5) deficiency disorder (CDD) is a devastating rare neurodevelopmental disease without a cure, caused by mutations of the serine/threonine kinase CDKL5 highly expressed in the forebrain. CDD is characterized by early-onset seizures, severe intellectual disabilities...

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Detalles Bibliográficos
Autores principales: Gurgone, Antonia, Pizzo, Riccardo, Raspanti, Alessandra, Chiantia, Giuseppe, Devi, Sunaina, Comai, Debora, Morello, Noemi, Pilotto, Federica, Gnavi, Sara, Lupori, Leonardo, Mazziotti, Raffaele, Sagona, Giulia, Putignano, Elena, Nocentini, Alessio, Supuran, Claudiu T., Marcantoni, Andrea, Pizzorusso, Tommaso, Giustetto, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156697/
https://www.ncbi.nlm.nih.gov/pubmed/35945276
http://dx.doi.org/10.1038/s41386-022-01412-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156697/
https://www.ncbi.nlm.nih.gov/pubmed/35945276
http://dx.doi.org/10.1038/s41386-022-01412-3

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