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Systemic kappa opioid receptor antagonism accelerates reinforcement learning via augmentation of novelty processing in male mice

Selective inhibition of kappa opioid receptors (KORs) is highly anticipated as a pharmacotherapeutic intervention for substance use disorders and depression. The accepted explanation for KOR antagonist-induced amelioration of aberrant behaviors posits that KORs globally function as a negative valenc...

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Detalles Bibliográficos
Autores principales: Farahbakhsh, Zahra Z., Song, Keaton, Branthwaite, Hannah E., Erickson, Kirsty R., Mukerjee, Snigdha, Nolan, Suzanne O., Siciliano, Cody A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156709/
https://www.ncbi.nlm.nih.gov/pubmed/36804487
http://dx.doi.org/10.1038/s41386-023-01547-x