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Systemic kappa opioid receptor antagonism accelerates reinforcement learning via augmentation of novelty processing in male mice
Selective inhibition of kappa opioid receptors (KORs) is highly anticipated as a pharmacotherapeutic intervention for substance use disorders and depression. The accepted explanation for KOR antagonist-induced amelioration of aberrant behaviors posits that KORs globally function as a negative valenc...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10156709/ https://www.ncbi.nlm.nih.gov/pubmed/36804487 http://dx.doi.org/10.1038/s41386-023-01547-x |